She usually has great chemistry with her leading men, but my favourites are:
1.) Michael Keaton 2.) Jack Nicholson 3.) Daniel Day Lewis
I have to disagree, she has had some of the most popular male leads. But she has only had any real heat with a hand few of them IMO. I will say she shares a special chemistry with Jack Nicholson, I still, believe she would have done a greater job than Helen hunt with him in as good as it gets lol.